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What is the cause of hyperaldosteronism? Primary hyperaldosteronism is due to a problem of the adrenal glands themselves, which causes them to release too much aldosterone. Most cases of primary hyperaldosteronism are caused by a noncancerous (benign) tumor of the adrenal gland. The condition is most common in people 30 to 50 years old.
What are side effects of spironolactone? Common Side Effects of Spironolactone Vomiting, diarrhea, and stomach pain or cramps. Dry mouth and thirst. Dizziness, unsteadiness, and headache. Gynecomastia (enlarged breast tissue) in men, and breast pain in women. Irregular menstrual periods and post-menopausal vaginal bleeding. Erectile dysfunction.
Does spironolactone increase aldosterone levels? In the group of patients submitted to spironolactone treatment the proportion of patients with renin and aldosterone levels above the cutoff had a significant increase from baseline to day 3 (24–32% and 16–44%, respectively, both p < 0.05).
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